The Ataxia (axJ) Mutation Causes Abnormal GABAA Receptor Turnover in Mice
On Universality in Human Correspondence Activity
R. D. Malmgren et al.
ヒトの手紙のやりとりのネットワークの特徴。circadian cycle, task repetition, and changing communication needs. アインシュタインを例に。emailと手紙の比較。
Genetic perturbation of postsynaptic activity regulates synapse elimination in developing cerebellumErika Lorenzetto, Luana Caselli, Guoping Feng, Weilong Yuan, Jeanne M. Nerbonne, Joshua R. Sanes, and Mario Buffelli
L7下にクロライドチャネルを発現するとclimbing fiberのmultile innervationが持続する。
Cooperative synapse formation in the neocortex
Christiaan P. J. de Kock and Bert Sakmann
awake, head-restrained ラットバレル。whiskingはL5Aの細胞の発火頻度を特異的に増加させる。
Nature Reviews Neuroscience
The origin and evolution of synapses
Tomas J. Ryan and Seth G. N. Grant
Evolution of the neocortex: a perspective from developmental biology
Frontiers in interative neuroscience
Remote radio control of insect flight
The timing of external input controls the sign of plasticity at local
synapses pp1219 - 1221
Jeehyun Kwag and Ole Paulsen
This paper shows that synapses between CA1 pyramidal cells in the
hippocampus and the tempero-ammonic pathway in the entorhinal cortex
undergo spike timing-dependent plasticity.
Selective suppression of hippocampal ripples impairs spatial memory
pp1222 - 1223
Gabrielle Girardeau, Karim Benchenane, Sidney I Wiener, Gyorgy Buzsaki
and Michael B Zugaro
Sharp wave-ripple (SPW-R) complexes during sleep or rest have yet to
be causally linked to memory consolidation. Here, the authors show that
suppressing hippocampal SPW-Rs during post-training sleep in rats impairs
the consolidation of a hippocampus-dependent spatial memory task.
Integration of neuronal clones in the radial cortical columns by
EphA and ephrin-A signalling pp524-528
During development of the cerebral cortex, excitatory projection
neurons migrate to form a cellular infrastructure of radial
columns. However, some of these clonally related neurons undergo
a lateral shift to intermix with neurons originating from
neighbouring proliferative units. This process is now shown
to be dependent on Eph receptor A and ephrin A signalling, a
so far unrecognized mechanism for lateral neuronal dispersion
that seems to be essential for the proper intermixing of
neuronal types in the cortical columns.
Masaaki Torii, Kazue Hashimoto-Torii, Pat Levitt and Pasko Rakic
Fgf8 morphogen gradient forms by a source-sink mechanism with
freely diffusing molecules pp533-536
Concentration gradients of certain molecules termed 'morphogens' are
known to control tissue development during embryogenesis, but how
exactly these gradients are formed remains unclear. Using the
technique of fluorescence correlation spectroscopy, Fgf8 morphogen
gradients are now shown to be established and maintained in living
zebrafish by two essential factors: free diffusion of single molecules
away from the source and a sink function of the receiving cells.
Shuizi Rachel Yu et al.
Cellular Basis of Itch Sensation
Yan-Gang Sun, Zhong-Qiu Zhao, Xiu-Li Meng,Jun Yin, Xian-Yu Liu, Zhou-Feng Chen
Itch and pain are two distinct sensations. Although our previous study suggested that gastrin-releasing peptide receptor (GRPR) is an itch-specific gene in the spinal cord, a long-standing question of whether there are separate neuronal pathways for itch and pain remains unsettled. We selectively ablated lamina I neurons expressing GRPR in the spinal cord of mice. These mice showed profound scratching deficits in response to all of the itching (pruritogenic) stimuli tested, irrespective of their histamine dependence. In contrast, pain behaviors were unaffected. Our data also suggest that GRPR+ neurons are different from the spinothalamic tract neurons that have been the focus of the debate. Together, the present study suggests that GRPR+ neurons constitute a long-sought labeled line for itch sensation in the spinal cord.
Charles C. Lee and S. Murray Sherman
Glutamatergic Inhibition in Sensory Neocortex
Nina Bien, Alard Roebroeck, Rainer Goebel, and Alexander T. Sack
The Brain's Intention to Imitate: The Neurobiology of Intentional versus
Within the identified connectivity network, right middle/inferior frontal cortex sends neural input concerning general response inhibition to right premotor cortex, which is involved in automatic imitation. Subsequently, the fully prepared imitative response is sent to left opercular cortex that functions as a final gating mechanism for intentional imitation.
Perineuronal Nets Protect Fear Memories from Erasure
N. Gogolla et al.
Fearful memories in adults are difficult to erase because of the physical environment of specific neurons in the brain.
Differential Sensitivity to Human Communication in Dogs, Wolves, and Human Infants
J. Topál et al.
Social interactions with humans govern the way dogs and children learn, but wolves learn by focusing on objects.
PLoS Computational Biology
Towards Reproducible Descriptions of Neuronal Network Models
Eilen Nordlie, Marc-Oliver Gewaltig, Hans Ekkehard Plesser
Two-photon excitation of channelrhodopsin-2 at saturation
John Peter Rickgauer and David W. Tank
Sparsification of neuronal activity in the visual cortex at eye-opening
Nathalie L. Rochefort, Olga Garaschuk, Ruxandra-Iulia Milos, Madoka Narushima, Nima Marandi, Bruno Pichler, Yury Kovalchuk, and Arthur Konnerth
A genetically encoded photoactivatable Rac controls the motility of
living cells pp104-108
The precise spatiotemporal dynamics of protein activity remain poorly
understood, yet they can be critical in determining cell behaviour. A
genetically encoded, photoactivatable version of the protein Rac1, a
key GTPase regulating actin cytoskeletal dynamics, has now been
produced; this approach enables the manipulation of the activity of
Rac1 at precise times and places within a living cell, thus controlling
Yi I. Wu et al.
The Representation of Tool Use in Humans and Monkeys: Common and Uniquely
R. Peeters, L. Simone, K. Nelissen, M. Fabbri-Destro, W. Vanduffel, G.
Rizzolatti, and G. A. Orban
In humans, the observation of actions done with simple tools yielded an additional, specific activation of a rostral sector of the left inferior parietal lobule (IPL). This latter site was considered human-specific, as it was not observed in monkey IPL for any of the tool videos presented, even after monkeys had become proficient in using a rake or pliers through extensive training.
The evolution of information suppression in communicating robots with conflicting interests Sara Mitri, Dario Floreano, and Laurent Keller
Mitochondrial gene replacement in primate offspring and embryonic
stem cells pp367-372
The mitochondrial genome is of maternal origin and mutations in
mitochondrial DNA are the cause of many human diseases. The efficient
replacement of the mitochondrial genome in mature non-human primate
oocytes is now demonstrated. This approach may offer a reproductive
option to prevent the transmission of diseases caused by mutations
in mitochondrial DNA in affected families.
Masahito Tachibana et al.
KDM1B is a histone H3K4 demethylase required to establish maternal
genomic imprints pp415-418
In mammals, the parental origin-specific expression of imprinted
genes is known to be regulated by differential DNA methylation of
paternal and maternal alleles, but it is unclear how particular
imprinted loci are selected for de novo DNA methylation during
gametogenesis. Here it is shown that AOF1, or KDM1B under new
nomenclature, functions as a histone H3 lysine 4 demethylase and
is required for de novo DNA methylation of some imprinted genes
David N. Ciccone et al.
Inferring friendship network structure by using mobile phone data Nathan Eagle, Alex (Sandy) Pentland, and David Lazer
Honey bee aggression supports a link between gene regulation and behavioral evolution
Cédric Alaux, Saurabh Sinha, Linda Hasadsri, Greg J. Hunt, Ernesto Guzmán-Novoa, Gloria DeGrandi-Hoffman, José Luis Uribe-Rubio, Bruce R. Southey, Sandra Rodriguez-Zas, and Gene E. Robinso
Non-Hebbian Synaptic Plasticity Induced by Repetitive Postsynaptic Action
Hiroyuki K. Kato, Ayako M. Watabe, and Toshiya Manabe
Does Retinotopy Influence Cortical Folding in Primate Visual Cortex?
Reza Rajimehr and Roger B. H. Tootell
ヒトと沙流のMRI画像で視覚野の網膜地図はvertical meridianがgyriに、horizontal meridianがsulciになる傾向がある。